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Related Experiment Videos

Cell membrane array fabrication and assay technology.

Victoria Yamazaki1, Oksana Sirenko, Robert J Schafer

  • 1Synamem Corporation, 863 Mitten Road, Suite 101, Burlingame, CA 94010, USA. vyamazaki@synamem.com

BMC Biotechnology
|June 18, 2005
PubMed
Summary
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This study introduces a novel fluid cell membrane array technology for high-throughput biological studies. This innovation enables detailed analysis of ligand/receptor interactions and cell signaling for research and drug discovery.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biotechnology

Background:

  • Microarray technology is widely used for gene expression analysis.
  • Arraying cell membranes while preserving biochemical function is challenging.

Purpose of the Study:

  • To develop a novel technology for creating fluid cell membrane microarrays.
  • To enable high-throughput studies of cellular processes and interactions.

Main Methods:

  • Robotically arrayed supported membranes with fluid lipid bilayers.
  • Incorporation of biologically active molecules and transmembrane proteins.
  • Investigation of cholera toxin B-subunit (CTB) binding to GM1.

Main Results:

  • Physiologically fluid membranes that support biological activity.

Related Experiment Videos

  • Enabled study of ligand/receptor binding and interactions with live cells.
  • Demonstrated utility for studying multivalent binding and drug targets like LPS.

    • Conclusions:

    • The fluid cell membrane array technology is applicable to academic research and industrial drug discovery.
    • Facilitates detailed study of ligand/receptor interactions and cell-cell signaling.
    • Provides rich qualitative and quantitative data for biological investigations.