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Updated: Aug 17, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Primary melanoma of the rectum: an infrequent neoplasia with an atypical presentation]
Elena Solaz Moreno1, Manuel Vallalta Morales, Gerardo Silla Búrdalo
1Servicio de Medicina Interna, Hospital Universitario La Fe, Valencia, España.
Abstract:
Primary anorectal melanoma is a rare malignancy with an extremely aggressive biological behaviour. The main clinical presentations are local symptoms such as rectal bleeding, anal mass or pain, or a change in bowel habits. The tumour is frequently mistaken for benign conditions as haemorrhoids or rectal polyps. Many treatments can be used: surgery, chemotherapy, radiotherapy, immunotherapy and even bio-therapy. Despite this, the disease has a very poor prognosis and 10% of patients survive 5 years.
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