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Updated: May 5, 2026

Invasion of Human Cells by a Bacterial Pathogen
Published on: March 21, 2011
Anchors away! Fos fosters anchor-cell invasion
1Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.
Abstract:
Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo is described. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).
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