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Inflammatory response after acute ischemic stroke.

Lars Marquardt1, Andreas Ruf, Ulrich Mansmann

  • 1Department of Neurology, Klinikum Ludwigshafen, Bremserstrasse 79, Ludwigshafen 67063, Germany. marquarl@klilu.de

Journal of the Neurological Sciences
|June 18, 2005
PubMed
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Inflammatory markers like fibrinogen and leukocytes show varied responses after ischemic stroke. Aspirin treatment may reduce these inflammatory parameters in the subacute phase.

Area of Science:

  • Neurology
  • Immunology
  • Biochemistry

Background:

  • Acute ischemic stroke triggers complex physiological responses.
  • Inflammation plays a critical role in stroke pathophysiology and outcomes.

Purpose of the Study:

  • To characterize the temporal dynamics of key inflammatory markers post-ischemic stroke.
  • To compare inflammatory profiles in stroke patients versus control groups.
  • To investigate correlations between inflammatory markers and stroke severity or characteristics.

Main Methods:

  • Serial measurements of high-sensitivity C-reactive protein (CRP), fibrinogen, and leukocyte counts.
  • Data collected at 10 time points from day 1 to day 90 post-stroke.
  • Comparison with healthy and risk-factor-matched control subjects.

Related Experiment Videos

Main Results:

  • Fibrinogen levels increased post-stroke, while leukocyte counts initially rose then declined.
  • CRP and fibrinogen remained elevated compared to healthy controls, but not risk-factor controls.
  • Leukocyte elevation was significant only on day 1 post-stroke.
  • Higher NIHSS scores correlated with elevated CRP and fibrinogen.
  • Larger infarcts associated with higher day 90 CRP and leukocyte counts.
  • Aspirin treatment linked to lower inflammatory markers in the subacute phase.

Conclusions:

  • Inflammatory marker kinetics differ significantly after ischemic stroke.
  • Leukocytes exhibited characteristics of an acute phase response.
  • Findings suggest distinct roles for CRP, fibrinogen, and leukocytes in stroke inflammation.