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Free oxygen radical-induced lipid peroxidation and antioxidant in infants receiving total parenteral nutrition

Alev Hasanoğlu1, Nazan Dalgiç, Leyla Tümer

  • 1Faculty of Medicine, Department of Pediatrics, Gazi University, Ankara, Turkey.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|June 18, 2005
PubMed

Insights

Total parenteral nutrition (TPN) increases free radical activity in infants, potentially causing adverse effects. Partial enteral feeding may help mitigate these complications by supporting antioxidant defenses.

Area of Science:

  • Biochemistry
  • Neonatal Nutrition
  • Pediatric Gastroenterology

Background:

  • Total parenteral nutrition (TPN) is associated with increased oxygen-derived free radical activity, particularly during lipid infusion in infants.
  • Partial enteral feeding may offer a strategy to reduce TPN-related complications.

Purpose of the Study:

  • To investigate free radical formation and antioxidant activity in term and preterm infants receiving TPN and/or enteral feeding.
  • To compare oxidative stress markers between infants receiving different feeding modalities.

Main Methods:

  • Six groups of 10 term and preterm infants were studied: enteral feeding only, enteral plus parenteral feeding, and parenteral feeding only.
  • Plasma malondialdehyde (MDA), superoxide dismutase (SOD), vitamin E, and vitamin C levels were measured.
  • Measurements were taken at baseline, on days 1 and 5 of TPN, and 3 hours post-lipid infusion.

Main Results:

  • No significant differences in MDA, SOD, vitamin C, or E were observed between term and preterm infants across feeding groups on days 1 and 5.
  • MDA levels were higher before TPN in term infants receiving both parenteral and enteral feeding compared to those on parenteral nutrition alone on day 5.
  • Vitamin C levels decreased, vitamin E levels increased, and SOD levels were elevated in term infants on TPN compared to baseline.

Conclusions:

  • TPN administration increases free radical production, potentially contributing to adverse effects in infants.
  • Enhancing antioxidant capacity within TPN solutions may be crucial for reducing long-term complications in preterm infants.
Abstract

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