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Effects of chronic ethanol consumption on the rat parotid gland
J A Banderas1, L A Gaitan, J Portilla
1Department of Oral Pathology, School of Dental Medicine, National Autonomous University of Mexico, Mexico City.
Archives of Oral Biology
|January 1, 1992
Abstract:
Two-month-old Wistar rats ingested 10% ethanol for 12 months. Their parotid glands were then compared with those of normal controls by light microscopy. They had extensive ductal and acinar oncocytic transformation; numerous atypical acinar cells showed anisocytosis, polyploidism and hyperchromatism, features that were absent in controls. Oncocytosis and atypical acinar cells have been reported in 2-3-yr-old ('senile') Wistar rats. Thus, chronic alcohol ingestion may produce cellular features resembling those observed in the parotid gland of 'senile' Wistar rats.