Related Experiment Videos
Endophthalmitis caused by streptococcal species
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 11, 1992
Summary
Streptococcal endophthalmitis, often post-operative, showed varied outcomes. Vancomycin was effective, while gentamicin resistance was noted in these serious eye infections.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Streptococcal endophthalmitis is a severe intraocular infection.
- Understanding causative agents and treatment outcomes is crucial for patient management.
Purpose of the Study:
- To review clinical features, microbiological profiles, and treatment outcomes of streptococcal endophthalmitis.
- To assess antibiotic susceptibility patterns of isolated streptococcal species.
Main Methods:
- Retrospective review of 48 patients with culture-positive streptococcal endophthalmitis (January 1977 - May 1990).
- Analysis of patient demographics, etiology, causative streptococcal species, and visual acuity outcomes.
- In vitro susceptibility testing against gentamicin sulfate and vancomycin hydrochloride.
Main Results:
- Viridans group streptococci (50%) and enterococci (27.1%) were the most common isolates.
- Postoperative cases constituted the majority (83.3%).
- Overall visual acuity of 20/400 or better was achieved by 31.2% of patients.
- 32.6% of isolates showed gentamicin resistance; all were sensitive to vancomycin.
- Enterococci exhibited cephalosporin resistance, unlike other streptococcal species.
Conclusions:
- Streptococcal endophthalmitis presents significant visual morbidity, frequently linked to postoperative settings.
- Vancomycin hydrochloride demonstrates consistent in vitro efficacy against streptococcal isolates.
- Gentamicin and cephalosporin resistance patterns necessitate careful antibiotic selection in managing these infections.