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Updated: Aug 17, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
Mechanisms of the blood-brain barrier disruption in HIV-1 infection
Michal Toborek1, Yong Woo Lee, Govinder Flora
1Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA. mjtobo00@uky.edu
Abstract:
(1) Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). (2) It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. (3) The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.
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