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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Exposure time to hepatitis B virus and associated risk factors among children in Edirne, Turkey

M Otkun1, M S Erdogan, M Tatman-Otkun

  • 1Department of Microbiology and Clinical Microbiology, Medical Faculty of Trakya University, Edirne, Turkey.

Epidemiology and Infection
|June 21, 2005
PubMed

Insights

Hepatitis B virus (HBV) infection risk increases after age 10 in Turkish children. Collective circumcision was a significant risk factor, highlighting the need for early vaccination.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Hepatitis B virus (HBV) infection is a significant public health concern, particularly in endemic regions like Turkey.
  • Understanding transmission routes and risk factors in children is crucial for effective prevention strategies.

Purpose of the Study:

  • To determine the timing of Hepatitis B virus (HBV) exposure in children aged 0-19 years in Edirne, Turkey.
  • To identify associated risk factors for HBV infection in this pediatric population.

Main Methods:

  • A cross-sectional study involving 717 children aged 0-19 years in Edirne.
  • Screening for antiHBc, antiHBs, and HBsAg using the microELISA method.
  • Data collection through questionnaires to assess potential risk factors.

Main Results:

  • Overall antiHBc seropositivity was 5.4%, with rates increasing significantly in older age groups (11.8% in 15-19 years).
  • HBsAg seropositivity was 1.7%.
  • The risk of HBV infection increased notably after age 10 (OR 7.79), with collective circumcision identified as the sole independent risk factor via regression analysis.

Conclusions:

  • HBV infection risk in children increases substantially after the age of 10.
  • Collective circumcision is a significant risk factor for HBV transmission in children.
  • Vaccination against HBV before 11 years of age is recommended for children in Edirne.

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