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Angiogenesis inhibitors found within the haemostasis pathway
Carolyn A Staton1, Claire E Lewis
1Microcirculation Research Group, University of Sheffield Medical School, Sheffield, S10 2RX, UK.
Journal of Cellular and Molecular Medicine
|June 21, 2005
Summary
Cancer growth is linked to new blood vessel formation (angiogenesis) and blood clotting (haemostasis). This review explores how haemostasis regulates angiogenesis and highlights endogenous proteins with anti-cancer potential.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Angiogenesis and haemostasis are consistent host responses in cancer.
- These processes are interconnected, with coagulation influencing tumor growth.
- Platelets and haemostatic proteins contain endogenous angiogenesis inhibitors.
Purpose of the Study:
- To review the coordination and regulation of angiogenesis by haemostasis in human cancer.
- To detail evidence for endogenous proteins inhibiting tumor angiogenesis.
- To explore the potential of these proteins as anti-cancer agents.
Main Methods:
- Literature review of experimental and pre-clinical studies.
- Analysis of endogenous proteins involved in haemostasis and angiogenesis.
- Examination of clinical trial data where available.
Main Results:
- Haemostasis significantly influences tumor angiogenesis and growth.
- Numerous endogenous proteins, derived from haemostatic pathways, inhibit angiogenesis.
- These proteins show promise as therapeutic anti-cancer agents.
Conclusions:
- The interplay between haemostasis and angiogenesis is crucial in cancer.
- Endogenous haemostatic proteins represent a potential source of novel anti-cancer therapies.
- Further clinical investigation of these agents is warranted.