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International Salmonella Typhimurium DT104 infections, 1992-2001

Morten Helms1, Steen Ethelberg, Kåre Mølbak

  • 1Statens Serum Institut, Copenhagen, Denmark. mhe@ssi.dk

Emerging Infectious Diseases
|June 21, 2005
PubMed

Insights

Multidrug-resistant Salmonella Typhimurium (MDR S. Typhimurium) infections, especially the DT104 strain, have risen globally. This increasing public health issue highlights the need for enhanced surveillance and control programs.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • The incidence of multidrug-resistant (MDR) Salmonella Typhimurium infections, particularly MDR definitive phage type 104 (DT104), has significantly increased globally over the past two decades.
  • This rise in MDR S. Typhimurium is often associated with increased human illness, posing a growing public health concern.

Purpose of the Study:

  • To assess the global magnitude of multidrug-resistant Salmonella Typhimurium and DT104 infections.
  • To examine trends in antimicrobial resistance and phage typing data for S. Typhimurium.

Main Methods:

  • A survey was conducted among 29 primarily industrialized countries using available antimicrobial resistance and phage typing surveillance data.
  • Data collection covered the period from 1992 to 2001.

Main Results:

  • The incidence of MDR S. Typhimurium and DT104 showed a continuous increase from 1992 to 2001, predominantly in Europe and North America.
  • While the increase appeared to peak in the United Kingdom, it continued in other countries. The incidence of quinolone-resistant S. Typhimurium also increased during this period.

Conclusions:

  • MDR S. Typhimurium represents a growing public health challenge in many parts of the world.
  • The findings underscore the critical importance of robust surveillance and effective control programs to manage the spread of MDR S. Typhimurium infections.

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