Reduced viral burden amongst high responder patients following HIV-1 p24 peptide-based therapeutic immunization
Anne-Marte B Kran1, Maja A Sommerfelt, Birger Sørensen
1Department of Infectious Diseases, Faculty Division Ullevaal University Hospital, University of Oslo, Kirkeveien 166, NO-0407 Oslo, Norway.
Abstract:
We have previously shown that HIV p24-like peptides (Vacc-4x) via activation of skin dendritic cells induced immune responses in 90% of HIV patients on highly active antiretroviral treatment (HAART). These patients (n=38) were here subjected to a final 14-week interruption of HAART. Patients with the highest delayed type hypersensitivity (DTH) responses to Vacc-4x-peptides before treatment interruption tended to achieve lower actual HIV RNA levels at the end of the study compared to Vacc-4x DTH low-responders (p=0.08) and significantly so in terms of viral loads relative to their individual pre-HAART HIV RNA set-points (p=0.04). CD4+ lymphocyte counts were maintained only among DTH high responders but decreased in the other patients during recurrent viremia (p
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