Related Experiment Videos
Development of activity standard for 90 Y microspheres
1Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights, NSW 2234, Australia. Imx@ansto.gov.au
Summary
Accurate measurement of SIR-spheres, a Yttrium-90 radiopharmaceutical for liver cancer, is crucial. A traceable national measurement standard was established using a chemical digestion process for Yttrium-90 solutions.
Area of Science:
- Nuclear Medicine
- Radiopharmaceutical Chemistry
- Medical Physics
Background:
- Yttrium-90 (90Y) microspheres are vital radiopharmaceuticals for liver cancer treatment via selective internal radiation therapy (SIRT).
- SIR-spheres, a commercial 90Y microsphere product, requires accurate activity measurement traceable to national standards for quality assurance.
Purpose of the Study:
- To establish a traceable national measurement standard for SIR-spheres activity.
- To develop a method for accurate quantification of 90Y microspheres in the SIR-spheres product.
Main Methods:
- A chemical digestion process was employed to convert SIR-spheres into a 90Y solution.
- The 90Y solution was used to create a traceable activity standard.
- Calibration factors for ionization chambers were determined using the established standard for different volumes (1 and 5 ml) and microsphere concentrations (34% and 44%).
Main Results:
- A quantifiable chemical digestion method was successfully developed for SIR-spheres.
- A traceable activity standard for SIR-spheres was established.
- Calibration factors were determined for ionization chambers, enabling accurate activity measurements of SIR-spheres.
Conclusions:
- The developed method allows for accurate and traceable activity measurements of SIR-spheres.
- This capability is essential for the quality control and therapeutic efficacy of SIR-spheres in liver cancer treatment.
- The study provides a foundation for ensuring the reliability of 90Y microsphere radiopharmaceuticals.