Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exocrine pancreas development in zebrafish.

Nelson S Yee1, Kristin Lorent, Michael Pack

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA.

Developmental Biology
|June 21, 2005
PubMed
Summary

Zebrafish exocrine pancreas development occurs in two stages: anlage formation and progenitor differentiation. Notch signaling is key for ductal differentiation, suggesting common pathways regulate gland and duct development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Associated with Stage at Diagnosis in Pancreatic Cancer: Implications for Precision Screening and Early Detection.

Biomedicines·2026
Same author

Editorial: Clinical implementation of precision oncology data to direct individualized and immunotherapy-based treatment strategies.

Frontiers in immunology·2025
Same author

Obscure Small Bowel Bleeding From Visceral Kaposi Sarcoma Without Cutaneous Manifestations.

The American journal of gastroenterology·2025
Same author

Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers.

Biomedicines·2025
Same author

Accuracy of Contrast-Enhanced Ultrasound for Hepatocellular Carcinoma Post-Transcatheter Arterial Embolization.

Journal of clinical medicine·2025
Same author

Complete response to chemotherapy in a 6-year survivor of metastatic pancreatic cancer.

BMJ case reports·2024

Area of Science:

  • Developmental biology
  • Comparative anatomy
  • Zebrafish models

Background:

  • Limited understanding of exocrine pancreas formation compared to endocrine pancreas.
  • Zebrafish as a model for studying exocrine pancreas development.
  • Unclear timing and mechanisms of acinar and ductal differentiation and morphogenesis.

Purpose of the Study:

  • Characterize zebrafish exocrine pancreas development in wild-type and mutant larvae.
  • Identify distinct stages of exocrine pancreas development.
  • Investigate the roles of molecular pathways, including Notch signaling, in exocrine pancreas development.

Main Methods:

  • Histological analysis
  • Immunohistochemical analysis
  • Ultrastructural analysis

Related Experiment Videos

  • Zebrafish mutant and morpholino knockdown studies

    • Main Results:

    • Identified two stages: exocrine anlage formation and progenitor differentiation with morphogenesis.
    • Proposed a model for intrapancreatic ductal system development from progenitor networks, distinct from mammalian branching morphogenesis.
    • Demonstrated that Notch signaling primarily regulates ductal differentiation of bipotential exocrine progenitors.

    Conclusions:

    • Common molecular pathways likely regulate both acinar gland and duct morphogenesis and differentiation.
    • Notch signaling plays a principal role in the ductal differentiation of bipotential exocrine progenitors.
    • Zebrafish provide a valuable model for dissecting exocrine pancreas development mechanisms.