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HGF and postnatal testis development.

A Catizone1, G Ricci, M Galdieri

  • 1Department of Histology and Medical Embryology, School of Medicine, University of Rome La Sapienza, Via A. Scarpa 14, Rome 0061, Italy.

Molecular and Cellular Endocrinology
|June 21, 2005
PubMed
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Hepatocyte growth factor (HGF) is secreted by peritubular myoid cells throughout rat testicular development. Sertoli cells begin expressing HGF later, suggesting HGF regulates mammalian testicular function.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Cell Biology

Background:

  • Hepatocyte growth factor (HGF) is a key regulator of cellular functions via its receptor c-met.
  • Previous studies indicated HGF is secreted by peritubular myoid cells but not Sertoli cells in prepubertal rats.

Purpose of the Study:

  • To investigate the expression and secretion of HGF by testicular cells during postnatal development.
  • To determine the role of HGF in mammalian testicular function.

Main Methods:

  • Northern blot analysis to detect HGF mRNA expression.
  • Cell culture to assess HGF secretion.
  • Analysis of HGF expression in rat testicular cells at different postnatal ages.

Main Results:

Related Experiment Videos

  • HGF is expressed and secreted by peritubular myoid cells throughout postnatal testicular development.
  • Sertoli cells begin expressing detectable levels of HGF around 25 days of age.
  • HGF is expressed and secreted by Sertoli cells from 35-day-old rats and enhances c-met expression in these cells.

Conclusions:

  • HGF is consistently produced by peritubular myoid cells during postnatal testicular development.
  • Sertoli cells acquire the capacity to express and secrete HGF postnatally.
  • HGF is implicated as a crucial growth factor in regulating mammalian testicular function.