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Updated: Aug 17, 2026

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Published on: April 11, 2018
Long-term potentiation in spinal nociceptive systems--how acute pain may become chronic
Lars Jørgen Rygh1, Frode Svendsen, Atle Fiskå
1Section for Physiology, Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway. lars.jorgen.rygh@biomed.uib.no
Abstract:
Chronic pain is a major problem since it is difficult to treat and the understanding of the underlying neurobiology is sparse. The mechanisms underpinning the transition of acute into chronic pain remain unclear. However, long-term potentiation (LTP) in spinal nociceptive systems may be one such mechanism. Here, we briefly review the literature regarding LTP in spinal nociceptive systems including our own data on LTP in deep convergent nociceptive neurons. Furthermore, we discuss the role of this phenomenon in understanding the neurobiology of chronic pain and the possible therapeutic implications.
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