Related Experiment Video
Updated: Aug 17, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
Published on: April 16, 2012
Homeostasis and the age-associated defect of CD4 T cells
Susan Swain1, Karen Clise-Dwyer, Laura Haynes
1Trudeau Institute, 154 Algonquin Ave., Saranac Lake, NY 12983, USA. sswain@northnet.org
Abstract:
Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-cellular milieu and together these processes ensure that a population of naive CD4 T cells persists into old age. However, the naive CD4 T cells from aged animals show reduced IL-2 production, proliferation, helper function and effector generation and memory function. We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan.
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