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Related Experiment Videos

Aging, stress and the hippocampus.

D B Miller1, J P O'Callaghan

  • 1Chronic Stress and Neurotoxicology Laboratories, TMBB-HELD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health-CDC-NIOSH, Morgantown, WV 26505, USA. dum6@cdc.gov

Ageing Research Reviews
|June 21, 2005
PubMed
Summary
This summary is machine-generated.

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Brain aging and cognitive decline are influenced by stress. The hippocampus, crucial for memory and stress response, shows age-related changes, but interventions targeting its plasticity may combat decline.

Area of Science:

  • Neuroscience
  • Gerontology
  • Endocrinology

Background:

  • Aging leads to functional decline across body systems, with significant individual variability.
  • Increasing lifespan highlights the need to understand brain aging, particularly cognitive decline and dementias.
  • Stress and its impact on brain aging are areas of growing research interest.

Purpose of the Study:

  • To investigate age-related changes in the hippocampus.
  • To examine the role of the hypothalamic-pituitary-adrenal (HPA) axis in hippocampal aging.
  • To explore how stress and glucocorticoids contribute to hippocampal aging and cognitive impairment.

Main Methods:

  • Review of existing literature on hippocampal changes with age.
  • Analysis of the relationship between HPA axis function and hippocampal structure/function.

Related Experiment Videos

  • Examination of the effects of glucocorticoids on hippocampal neurons and cognition.

    • Main Results:

    • The aging hippocampus may undergo atrophy but not generalized cell/synapse loss.
    • Age-related cognitive impairments are linked to neurobiological alterations beyond cell loss.
    • While excessive glucocorticoids impair cognition and hippocampal integrity, this is not an inevitable consequence of aging.

    Conclusions:

    • The hippocampus remains a viable target for interventions against age-related cognitive decline.
    • Pharmacological, nutritional, or lifestyle strategies can potentially mitigate age-related hippocampal and brain aging.
    • Preserved cellular integrity and plasticity in the aging hippocampus offer hope for therapeutic development.