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Link between the ciliary process and lens equatorial current.

S P Walsh1, J Sullivan, J W Patterson

  • 1Department of Physiology, University of Connecticut Health Center, Farmington 06032.

Lens and Eye Toxicity Research
|January 1, 1992
PubMed
Summary
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Seasonal changes significantly impact frog lens equatorial currents, with norepinephrine application affecting these currents. The ciliary process epithelium plays a role in regulating these physiological changes.

Area of Science:

  • Ophthalmology
  • Physiology
  • Neuroendocrinology

Background:

  • Intraocular pressure (IOP) exhibits circadian and seasonal variations.
  • These changes are influenced by the nervous system and norepinephrine release in the eye.
  • The equatorial current of the lens is a key electrophysiological parameter in ocular physiology.

Purpose of the Study:

  • To investigate the relationship between seasonal changes and the frog lens equatorial current.
  • To determine the effect of topical norepinephrine application on the lens equatorial current.
  • To explore the role of the ciliary process epithelium in modulating lens equatorial current.

Main Methods:

  • Utilized a vibrating probe and microelectrodes to measure the K+ electrical loop and equatorial current (J) in frog lenses (Rana pipiens).

Related Experiment Videos

  • Analyzed electrophysiological parameters of 270 normal frog lenses throughout the year.
  • Assessed the impact of direct and topical norepinephrine application on lens equatorial current (J) and resistance (RJ).

    • Main Results:

    • Observed threefold seasonal variations in equatorial current (J) amplitude and resistance (RJ).
    • Equatorial current (J) was highest in winter, while resistance (RJ) peaked in late spring.
    • Topical norepinephrine application increased the lens equatorial current, whereas direct application had no effect.

    Conclusions:

    • The magnitude of the frog lens equatorial current exhibits significant seasonal fluctuations.
    • Norepinephrine, applied topically, modulates the lens equatorial current.
    • The ciliary process epithelium is implicated in mediating the regulation of the lens equatorial current.