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Related Experiment Videos

Microglial stability and repopulation in the retina.

T A Albini1, R C Wang, B Reiser

  • 1Doheny Eye Institute, DVRC 211, 1450 San Pablo Street, Los Angeles, CA 90033, USA.

The British Journal of Ophthalmology
|June 21, 2005
PubMed
Summary
This summary is machine-generated.

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Retinal microglia, like brain microglia, are stable and slowly repopulated by bone marrow monocytes. Bone marrow derived monocytes may take up to a year to repopulate the retina in chimeric rats.

Area of Science:

  • Immunology
  • Neuroscience
  • Ophthalmology

Background:

  • Microglia in the central nervous system are slowly repopulated by bone marrow derived monocytes.
  • The contribution of bone marrow derived monocytes to the uninflamed retina remains unstudied.

Purpose of the Study:

  • To investigate the repopulation of retinal microglia by bone marrow derived monocytes in uninflamed bone marrow chimeric rats.

Main Methods:

  • Bone marrow chimeric Lewis rats were created by transplanting male bone marrow cells into lethally irradiated female recipients.
  • Samples of retina, brain, lung, and spleen were collected at various time points post-transplant (8, 10, 12, 30, 52 weeks).
  • Polymerase chain reaction was used to detect Y chromosome positive cells, indicating bone marrow derived cell infiltration.

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Main Results:

  • Rapid repopulation of spleen and lung tissues by bone marrow derived cells was observed.
  • No significant repopulation of brain parenchyma or retina by bone marrow derived cells was detected until 52 weeks post-transplant.

Conclusions:

  • Retinal microglia, similar to brain microglia, exhibit stability in number within the retinal compartment for up to one year.
  • Repopulation of the retina by bone marrow derived cells may be significantly delayed, potentially taking up to a year.