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Updated: Aug 17, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
Published on: May 23, 2025
Restless legs syndrome and low brain iron levels in patients with haemochromatosis
J Haba-Rubio1, L Staner, C Petiau
1Institute for Research in Neurosciences and Neuropsychiatry, Rouffach, France. Jose.HabaRubio@hcuge.ch
Abstract:
Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2' magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2' relaxation rates in the patients were decreased in the substantia nigra, red nucleus, and pallidum when compared with the controls. These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS.
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