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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Intracellular signalling controlling integrin activation in lymphocytes

Tatsuo Kinashi1

  • 1Department of Molecular Genetics, Graduate School of Medicine, Institute of Liver Research, Kansai Medical School, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan. kinashi@takii.kmu.ac.jp

Nature Reviews. Immunology
|June 21, 2005
PubMed

Since the discovery that integrins at the surface of lymphocytes undergo dynamic changes in their adhesive activity after stimulation through the T-cell receptor or stimulation with chemokines, intensive research has been carried out in an attempt to clarify the signalling events that lead to the activation of integrins. Whereas structural studies have provided us with a vivid picture of the conformational flexibility of integrins, the signalling pathways that regulate these conformational changes (known as inside-out signalling) have been elusive. However, as I discuss here, recent studies have provided new insight into the pathways that control the regulation of integrin activity and the coordination of complex cellular functions, such as the homing of lymphocytes and the formation of an immunological synapse.

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