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Standard-dose and short-term corticosteroid therapy in immunoglobulin-resistant Kawasaki disease

Seiichiro Takeshita1, Youichi Kawamura, Keigo Nakatani

  • 1University of Shizuoka, Shizuoka 422-8021, Japan.

Clinical Pediatrics
|June 21, 2005
PubMed

Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose). Five patients responded immediately to the first course of prednisolone infusion. One patient failed to respond to the first course of prednisolone therapy, but he did respond to the second 3-day course of therapy. None of the patients demonstrated a further progression of coronary artery dilatation or any adverse effects. Standard-dose and short-term corticosteroid therapy therefore appears to be a safe and effective treatment for patients with IVIG-resistant KD.

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