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Is decrease of tumor volume correlated with stage change after preoperative concurrent chemoradiotherapy?
Shung-Haur Yang1, Rheun-Chuan Lee, Chien-Chih Chen
1Division of Colon and Rectal Surgery, Department of Surgery, Cancer Center Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Hepato-Gastroenterology
|June 22, 2005
Summary
Tumor volume reduction after chemoradiotherapy (CCRT) is significant for rectal adenocarcinoma. Larger initial tumors showed greater volume reduction, while smaller tumors had a higher chance of complete response.
Area of Science:
- Oncology
- Radiotherapy
- Medical Imaging
Background:
- Concurrent chemoradiotherapy (CCRT) is a standard treatment for rectal adenocarcinoma.
- Evaluating tumor volume changes can provide insights into treatment response.
Purpose of the Study:
- To assess the significance of tumor volume and its change after CCRT in rectal adenocarcinoma.
- To correlate tumor volume metrics with pathological outcomes and clinical data.
Main Methods:
- 30 patients with middle and lower rectal adenocarcinoma received standard-dose external radiation and oral UFUR plus leucovorin.
- Dynamic MRI was used to calculate tumor volume before and after CCRT.
- Tumor volumes were compared with pathological results and clinical data.
Main Results:
- Tumor volume decreased significantly after CCRT (Vpre: 10.3cm³, VPost: 4.2cm³).
- Initial tumor volume (Vpre) correlated with T stage, N stage, age, and location.
- Net decrease ratio (NDR) of tumor volume correlated with Vpre and initial T stage.
- Vpre was related to complete response (CR) incidence, and NDR to N stage downstaging.
Conclusions:
- All tumors demonstrated volume reduction post-CCRT, though downstaging benefits varied.
- Larger initial tumors exhibited higher volume reduction ratios.
- Smaller initial tumors were associated with a higher likelihood of complete response.