Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue-specific immunoglobulin E in human nasal polyps.

Chih-Yen Wei1, Sheen-Yie Fang

  • 1Department of Otolaryngology, National Cheng Kung University Hospital, Tainan, Taiwan (ROC).

The Annals of Otology, Rhinology, and Laryngology
|June 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Fine Needle Aspiration Cytopathology in Salivary Gland Tumors under Milan System: Challenges, Misdiagnosis Rates, and Clinical Recommendations.

Biomedicines·2023
Same author

Idiopathic Sclerosing Orbital Inflammation in a Relapsing Polychondritis Patient With Impaired Vision.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2018
Same author

Investigating the association between diet and risk of head and neck cancer in Taiwan.

Oncotarget·2017
Same author

Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan.

Scientific reports·2017
Same author

Regular recreational physical activity and risk of head and neck cancer.

BMC cancer·2017
Same author

A Comprehensive Analysis on the Association between Tobacco-Free Betel Quid and Risk of Head and Neck Cancer in Taiwanese Men.

PloS one·2016
Same journal

Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

The Annals of otology, rhinology, and laryngology·2026
Same journal

Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

The Annals of otology, rhinology, and laryngology·2026
See all related articles

Investigating specific immunoglobulin E (sIgE) in nasal polyp tissue revealed that local sIgE levels more accurately indicate allergy-induced nasal polyps than serum tests or symptoms alone. This finding supports targeted antiallergic treatment.

Area of Science:

  • Immunology
  • Otolaryngology

Background:

  • Allergic rhinitis is a common cause of nasal polyps.
  • Accurate diagnosis of allergy-induced nasal polyps is crucial for effective treatment.

Purpose of the Study:

  • To define allergic nasal polyps by investigating specific immunoglobulin E (sIgE) within polyp tissue.
  • To compare the diagnostic value of local sIgE detection in polyp tissue versus systemic serum tests and clinical allergy symptoms.

Main Methods:

  • Collected 30 nasal polyp tissue samples from patients with allergic symptoms and 30 from those without.
  • Prepared nasal polyp tissue homogenates and patient serum for specific immunoglobulin E (sIgE) detection using the CAP method.
  • Analyzed the correlation between positive tissue CAP test results, serum CAP test results, and the presence of allergic symptoms.

Related Experiment Videos

Main Results:

  • Positive tissue CAP tests were observed in 36.7% of patients with allergic symptoms and 35.7% with positive serum CAP tests.
  • Nearly all patients with positive tissue CAP tests also exhibited allergic symptoms and positive serum CAP tests.
  • Local sIgE levels in polyp tissue demonstrated a more specific reflection of allergic status compared to serum tests or symptom presentation.

Conclusions:

  • The specific immunoglobulin E (sIgE) profile within nasal polyp tissue offers a more precise indicator of allergic involvement than systemic tests or symptom reporting.
  • Nasal polyp tissue CAP tests are recommended for patients with positive allergic symptoms and serum CAP tests to confirm allergy-induced polyps.
  • Precise identification of allergy-induced polyps can guide specific antiallergic treatments, potentially preventing polyp recurrence.