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Protein structure modeling in the proteomics era.

András Fiser1

  • 1Department of Biochemistry, Seaver Foundation Center for Bioinformatics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA. andras@fiserlab.org

Expert Review of Proteomics
|June 22, 2005
PubMed
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Structural proteomics seeks to understand protein structures and functions. This review covers advances in theoretical structure modeling, especially comparative modeling, to determine 3D protein structures for genome-scale projects.

Area of Science:

  • Structural biology
  • Computational biology
  • Proteomics

Background:

  • Structural proteomics investigates the 3D structures of proteins to understand their interactions and functions.
  • Determining 3D protein structures is crucial for understanding biochemical interactions.
  • The increasing number of gene sequences necessitates efficient methods for 3D structure determination.

Purpose of the Study:

  • To review the current state and recent advances in protein structure modeling.
  • To highlight the importance of theoretical approaches in supplementing experimental structure determination.
  • To focus on comparative protein structure modeling techniques.

Main Methods:

  • Review of existing literature on protein structure modeling.

Related Experiment Videos

  • Emphasis on comparative protein structure modeling techniques.
  • Discussion of theoretical approaches to supplement experimental methods.

    • Main Results:

    • Theoretical approaches, particularly comparative modeling, are essential for genome-scale 3D protein structure determination.
    • Advances in structure modeling accelerate the process of obtaining 3D protein structures.
    • Comparative modeling leverages known structures to predict unknown ones.

    Conclusions:

    • Theoretical structure modeling is vital for advancing structural proteomics.
    • Comparative protein structure modeling is a key technique for achieving genome-scale structural information.
    • Combining experimental and theoretical methods is crucial for future structural biology endeavors.