Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New approaches towards integrated proteomic databases and depositories.

Christian Rohlff1

  • 1Oxford Genome Sciences Ltd, 22 The Quadrant, Barton Lane, Abingdon Sciences Park, Abingdon, OX14 3YS, UK. cr@ogap.co.uk

Expert Review of Proteomics
|June 22, 2005
PubMed
Summary

Genomic and proteomic data integration faces challenges in protein identification and quantity. Bioinformatics solutions and initiatives like the Oxford Genome Anatomy Project are crucial for advancing proteomics and understanding the human genome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models.

Haematologica·2020
Same author

MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors.

Molecular cancer therapeutics·2019
Same author

Targeting CD157 in AML using a novel, Fc-engineered antibody construct.

Oncotarget·2017
Same author

Proteomic approaches in drug discovery and development.

International review of neurobiology·2004
Same author

Modern proteomic strategies in the study of complex neuropsychiatric disorders.

Biological psychiatry·2003
Same author

Proteomic approaches to central nervous system disorders.

Current opinion in molecular therapeutics·2002

Area of Science:

  • Genomics
  • Proteomics
  • Bioinformatics

Background:

  • The human genome's publication revealed uncertainties in protein-coding regions and a discrepancy between gene number and protein diversity.
  • Postgenomic challenges necessitate the integration of proteomic and genomic data.

Purpose of the Study:

  • To address postgenomic issues by integrating proteomic and genomic data.
  • To explore solutions for data management and mining in high-throughput proteomics.
  • To discuss the Oxford Genome Anatomy Project's framework for data integration.

Main Methods:

  • Leveraging proteomics technologies for postgenomic analysis.
  • Developing standard data formats for mass spectrometry data exchange (e.g., Proteomics Standards Initiative).
  • Utilizing public protein sequence databases (SwissProt, Uniprot) for functional annotation.

Related Experiment Videos

Main Results:

  • Proteomics offers potential solutions to postgenomic challenges but faces significant technological hurdles.
  • Standardization initiatives and public databases are emerging to manage proteomic data.
  • Bioinformatics is essential for realizing the full potential of proteomics.

Conclusions:

  • Overcoming data management and mining challenges is critical for proteomics advancement.
  • Integrated frameworks like the Oxford Genome Anatomy Project are needed to combine diverse biological data.
  • Accessible bioinformatics solutions will enhance the functional understanding of the human genome.