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Mass spectrometry-based quantitative proteomics.

Albert J R Heck1, Jeroen Krijgsveld

  • 1Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. a.j.r.heck@chem.uu.nl

Expert Review of Proteomics
|June 22, 2005
PubMed
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This review covers mass spectrometry techniques for quantitative proteomics, enabling global analysis of protein expression changes. Applications span cell biology to clinical research, advancing our understanding of biological systems.

Area of Science:

  • Proteomics
  • Biochemistry
  • Analytical Chemistry

Background:

  • Global protein expression analysis is a key goal in proteomics.
  • Mass spectrometry (MS) is established for protein identification.
  • Emerging MS methodologies enable protein quantification.

Purpose of the Study:

  • To review mass spectrometry-based technologies for quantitative proteomics.
  • To highlight diverse applications of quantitative proteomics.

Main Methods:

  • Review of mass spectrometry-based quantitative proteomics techniques.
  • Discussion of relevant scientific literature.

Main Results:

  • Mass spectrometry is a versatile tool for both protein identification and quantification.

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  • Quantitative proteomics using MS offers insights into biological processes.
  • Applications range from fundamental cell biology to clinical diagnostics.

    • Conclusions:

    • Mass spectrometry-based quantitative proteomics is a powerful approach.
    • This technology facilitates comprehensive analysis of proteomes.
    • It has broad utility across biological and medical research fields.