Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[UV-induced regulatory T cells].

Thomas Schwarz1

  • 1Klinik für Dermatologie, Venerologie und Allergologie, Christian-Albrechts-Universität zu Kiel. tschwarz@dermatology.uni-kiel.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|June 22, 2005
PubMed
Summary

Ultraviolet radiation suppresses immune responses via regulatory T cells (Tregs). These UV-induced Tregs, expressing CD4 and CD25, release interleukin-10 and migrate to lymph nodes, offering potential therapeutic applications for specific immunosuppression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The kinetochore proteins Ndc80 and Dsn1 are required for survival of postmitotic neurons.

bioRxiv : the preprint server for biology·2026
Same author

Loss of SARM1 Improves Phenotypes in a Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.

Neurology. Genetics·2026
Same author

An unusual granulomatous tinea due to <i>Nannizzia incurvata</i> in Germany without evidence of an acquisition from outside Europe and reduced itraconazole susceptibility.

Medical mycology case reports·2026
Same author

Bullous lichen sclerosus: A rare differential diagnosis of a blistering genital dermatosis.

JAAD case reports·2025
Same author

SARM1 loss protects retinal ganglion cells in a mouse model of autosomal dominant optic atrophy.

The Journal of clinical investigation·2025
Same author

ReBiA-Robotic Enabled Biological Automation: 3D Epithelial Tissue Production.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024

Area of Science:

  • Immunology
  • Dermatology
  • Photobiology

Background:

  • Regulatory T cells (Tregs) are crucial for preventing autoimmune diseases by suppressing immune reactions.
  • Ultraviolet (UV) radiation is known to induce antigen-specific immune suppression.
  • UV-induced Tregs are implicated in mediating this immunosuppressive effect.

Purpose of the Study:

  • To investigate the role and characteristics of UV-induced regulatory T cells.
  • To understand the mechanism of UV-induced immunosuppression.
  • To explore the therapeutic potential of UV-induced Tregs for inducing specific immunosuppression.

Main Methods:

  • Characterization of UV-induced regulatory T cells, including their surface markers (CD4, CD25) and cytokine production (interleukin-10).

Related Experiment Videos

  • Assessment of the migratory behavior of UV-induced Tregs following intravenous injection, particularly in lymph nodes.
  • Analysis of regulatory T cell development in an experimental photopheresis model.

    • Main Results:

    • UV-induced regulatory T cells express CD4 and CD25.
    • These cells release the immunosuppressive cytokine interleukin-10 upon activation.
    • UV-induced Tregs preferentially migrate to lymph nodes, suppressing sensitization.

    Conclusions:

    • UV radiation induces regulatory T cells that mediate antigen-specific immunosuppression.
    • These cells show potential for therapeutic applications in inducing targeted immunosuppression.
    • Further research into UV-induced Tregs could lead to novel treatments for immune-related disorders.