Related Experiment Video
Updated: Aug 17, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
Published on: October 20, 2020
Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery
C Martin1, J Thongborisute, H Takeuchi
1Vaccine Delivery Group, Centre for Drug Delivery Research, University of London, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
Abstract:
The aim of this study was to further investigate the interactions between cholesterol (CH) and mixed bile salts (BS) (sodium cholate and sodium deoxycholate) and their suitability for drug and vaccine delivery. Insulin was used as a model protein to assess the ability of CH:BS vesicles to entrap a therapeutically relevant macromolecule. The association of protein (FITC-insulin) with the CH:BS structure was confirmed with fluorescence microscopy, and the overall morphology of the vesicles was examined with atomic force microscopy (AFM). Results demonstrate that the nature of the vesicles formed between CH and BS is dependent not only on the concentration of BS but also on the increasing CH concentration leading to CH crystal formation.
More Related Videos
Related Concept Videos
Clathrin Coated Vesicles
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
COP Coated Vesicles
Receptor-mediated Endocytosis
Bioavailability Enhancement: Drug Permeability Enhancement

