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Updated: Aug 17, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and biological evaluation of novel angularly fused polycyclic coumarins
Imtyaz A Khan1, Manohar V Kulkarni, M Gopal
1Department of Chemistry, Karnatak University, Dharwad-580003, India.
Abstract:
In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.
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