Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonhuman primate models of asthma.

Robert L Coffman1, Edith M Hessel

  • 1Dynavax Technologies, Berkeley, CA 94710, USA. rcoffman@dvax.com

The Journal of Experimental Medicine
|June 22, 2005
PubMed
Summary

Asthma research faces challenges due to a lack of accurate animal models. Nonhuman primates offer a promising alternative to bridge the gap between human asthma and mouse models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.

Nature genetics·2026
Same author

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.

bioRxiv : the preprint server for biology·2026
Same author

Treatment of Shiga toxin-producing <i>E. coli</i> infection by CRISPR-Cas-targeted cleavage of the Shiga toxin gene in animal models.

Science translational medicine·2026
Same author

Allergic lung inflammation can be modulated by niacin and drives the development of glycolytic eosinophils.

Mucosal immunology·2026
Same author

A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists.

Vaccine·2026
Same author

Phase 2, Open-Label, Multicenter Study of Nelitolimod in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Advanced Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Area of Science:

  • Immunology
  • Pulmonology
  • Comparative Medicine

Background:

  • Asthma is a complex human respiratory disease with poorly understood immune mechanisms.
  • Current understanding relies heavily on human and mouse studies, which exhibit significant discrepancies.
  • Existing mouse models fail to accurately replicate spontaneous human asthma.

Purpose of the Study:

  • To highlight the limitations of current asthma models.
  • To advocate for the use of nonhuman primate models in asthma research.
  • To reconcile the differences observed between human and mouse asthma models.

Main Methods:

  • Comparative analysis of asthma pathogenesis in humans and model organisms.
  • Review of existing literature on asthma research in mice and nonhuman primates.
  • Identification of key immunological differences contributing to model system variability.

Main Results:

  • Significant fundamental differences exist between spontaneous human asthma and experimentally induced mouse asthma.
  • Nonhuman primate models demonstrate greater physiological and immunological similarity to human asthma.
  • Current mouse models may not fully capture the complexity of human asthma immune responses.

Conclusions:

  • Nonhuman primates represent a more suitable model for studying human asthma.
  • Further research utilizing nonhuman primate models is crucial for advancing asthma understanding.
  • Bridging the gap between human and mouse models is essential for developing effective asthma therapies.

Related Experiment Videos