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Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Stage IV micropapillary serous ovarian carcinoma: a report of three cases
Yong-Wook Kim1, Monica Srodon, Robert E Bristow
1The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Abstract:
Micropapillary serous carcinomas (MPSCs) have been distinguished from typical ovarian serous borderline tumors. Although the clinical features of MPSCs have been described in several studies, there is almost no clinicopathologic information regarding stage IV MPSC patients. We describe three cases of stage IV invasive MPSC with clinical and pathologic findings. One case had an umbilical metastasis (Sister Mary Joseph's nodule), and the other two cases had cytologically positive pleural effusions. These cases demonstrate the potential of MPSCs for aggressive clinical behavior and distant metastases.
Insights
Stage IV micropapillary serous carcinomas (MPSCs) can aggressively metastasize. This study details three cases, including umbilical and pleural metastases, highlighting MPSC
Area of Science:
- Gynecologic Oncology
- Pathology
Background:
- Micropapillary serous carcinomas (MPSCs) are distinct from ovarian serous borderline tumors.
- Limited clinicopathologic data exists for stage IV MPSCs.
Observation:
- Three stage IV invasive MPSC cases were analyzed.
- One patient presented with an umbilical metastasis (Sister Mary Joseph's nodule).
- Two patients had cytologically positive pleural effusions.
Findings:
- Stage IV MPSCs exhibit aggressive behavior.
- Distant metastases are a potential clinical manifestation of stage IV MPSCs.
Implications:
- These findings underscore the aggressive nature of MPSCs.
- Further research is needed to understand MPSC metastasis patterns and improve patient outcomes.
