Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis B Virus e Antigen Variants.

Shuping Tong1, Kyun-Hwan Kim, Charles Chante

  • 11. Liver Research Center, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA.

International Journal of Medical Sciences
|June 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient Photocatalytic Elimination of Imidazolinone Herbicides by Bismuth-Based Photocatalyst BiOIO<sub>3</sub>.

Molecules (Basel, Switzerland)·2026
Same author

The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

IFI35 suppresses the transcription of hepatitis B virus cccDNA minichromosome via promoting HNF4α proteasomal degradation.

Journal of biomedical science·2026
Same author

Integrative metabolomics and network pharmacology reveal the antifibrotic mechanisms of Gurigumu-13 in a rat model of hepatic fibrosis.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2026
Same author

Proteomics and phosphoproteomics of human colorectal cancer cells lacking a specific kinase activity reveal kinase-specific compensatory responses.

Animal cells and systems·2026
Same author

Corrigendum to "Prometastatic secretome trafficking via exosomes initiates pancreatic cancer pulmonary metastasis" [Cancer Lett. 481 (2020) 63-75].

Cancer letters·2025

Hepatitis B virus (HBV) immune escape mutants, particularly core promoter mutants, are selected during chronic infection. These mutants show enhanced replication and pathogenicity, contributing to severe liver disease.

Area of Science:

  • Virology
  • Immunology
  • Hepatology

Background:

  • Chronic hepatitis B virus (HBV) infection affects over 300 million worldwide.
  • The immune response is a major selective pressure during HBV infection.
  • Mutations arise during HBV replication, leading to immune escape variants.

Purpose of the Study:

  • To investigate the role of HBV immune escape mutants, specifically core promoter mutants, in disease pathogenesis.
  • To understand the virological properties of these mutants and their impact on disease severity.

Main Methods:

  • Analysis of HBV mutants selected during natural infection.
  • In vitro studies using transfected human hepatoma cells to assess viral replication.
  • Examination of mutations affecting HBeAg expression, translation, and virion secretion.

Related Experiment Videos

Main Results:

  • Core promoter mutants downregulate HBeAg expression and are associated with severe hepatitis and liver cancer.
  • These mutants exhibit up to 10-fold higher replication levels in cell culture compared to wild-type HBV.
  • Some mutants have impaired virion secretion due to envelope gene mutations.

Conclusions:

  • HBV core promoter mutants possess enhanced pathogenicity due to increased replication and altered protein expression.
  • These virological characteristics contribute to the development of severe liver disease in infected individuals.
  • Understanding these mutants is crucial for managing chronic HBV infection.