Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficient solid-phase synthesis of fullero-peptides using Merrifield strategy.

Alberto Bianco1

  • 1Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, Strasbourg, France. A.Bianco@ibmc.u-strasbg.fr

Chemical Communications (Cambridge, England)
|June 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reactivity and mechanistic insights into multistep silane functionalization of oxo-graphene.

Nanoscale·2026
Same author

A pH-responsive double network hydrogel for control of tomato bacterial wilt.

Nature communications·2026
Same author

Decoding Carbon Dot Purity by Nuclear Magnetic Resonance.

Angewandte Chemie (International ed. in English)·2026
Same author

Multifunctional amino acid-based nanoparticles for sequential drug delivery to overcome multidrug resistant cancer.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A pH/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers.

Biomaterials·2026

Researchers synthesized fullerene-containing peptides using a novel Boc-protected fullerene-glutamic acid derivative. This method leverages established solid-phase peptide synthesis techniques for efficient fullerene incorporation.

Area of Science:

  • Organic Chemistry
  • Materials Science
  • Biochemistry

Background:

  • Fullerenes are carbon allotropes with unique electronic and structural properties.
  • Incorporating fullerenes into peptides can create novel biomaterials with potential applications in medicine and nanotechnology.
  • Previous methods for synthesizing fullerene-peptide conjugates were often complex or low-yielding.

Purpose of the Study:

  • To develop a straightforward method for synthesizing fullerene-containing peptides.
  • To utilize Boc-protected l-fulleropyrrolidino-glutamic acid as a building block for peptide synthesis.
  • To demonstrate the compatibility of this building block with established solid-phase peptide synthesis protocols.

Main Methods:

  • Preparation of Boc-protected l-fulleropyrrolidino-glutamic acid.

Related Experiment Videos

  • Solid-phase peptide synthesis using Merrifield's Boc chemistry.
  • Purification and characterization of the resulting fullerene-peptide conjugates.

    • Main Results:

    • Boc-protected l-fulleropyrrolidino-glutamic acid was successfully synthesized.
    • The fullerene derivative was effectively incorporated into peptide chains using solid-phase Boc chemistry.
    • The method proved efficient for creating peptides functionalized with fullerenes.

    Conclusions:

    • The developed Boc-protected fullerene-glutamic acid is a valuable synthon for creating fullerene-peptide conjugates.
    • Solid-phase Boc chemistry provides a robust platform for the synthesis of these novel biomaterials.
    • This approach facilitates the exploration of fullerene-based peptides in various scientific fields.