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Colonic response to food in constipation.

Michel Bouchoucha1, Ghislain Devroede, Alain Faye

  • 1Laboratoire de Physiologie Digestive, Hôpital Broussais, Université Paris V, 96 rue Didot, 75014 Paris, France. michel.bouchoucha@brs.ap-hop-paris.fr

International Journal of Colorectal Disease
|June 22, 2005
PubMed
Summary

The colonic response to food is abnormal in many constipation patients. Different patterns of colonic response to food exist depending on the type of constipation, impacting gut motility.

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Area of Science:

  • Gastroenterology
  • Colorectal Physiology
  • Digestive System Function

Background:

  • Constipation is a common condition often associated with altered colonic function.
  • The relationship between food intake and colonic motility in constipated individuals requires further elucidation.

Purpose of the Study:

  • To investigate the colonic response to a meal in patients with constipation.
  • To characterize different patterns of colonic response based on constipation subtypes.

Main Methods:

  • Radiopaque markers were used to track colonic transit in 323 constipated patients and 60 healthy controls after a test meal.
  • Constipated patients were categorized into normal transit, colonic inertia, hindgut dysfunction, and outlet obstruction groups.
  • Colonic response was quantified by marker distribution and geometric center evolution.

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Main Results:

  • Healthy subjects show caecum-ascending colon emptying and rectosigmoid filling post-meal.
  • Constipated patients with normal transit exhibited a high incidence (41%) of absent colonic response to food.
  • Specific patterns of colonic response varied among constipation subtypes, with outlet obstruction showing no distal progress.

Conclusions:

  • Abnormal colonic response to food is a frequent finding in constipation.
  • The pattern of this abnormal response differs significantly across various types of constipation, including colonic inertia, hindgut dysfunction, and outlet obstruction.