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Hepatosplenic gammadelta T-cell lymphoma
Shuan-Zeng Wei1, Tong-Hua Liu, De-Tian Wang
1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
World Journal of Gastroenterology
|June 22, 2005
Summary
This study details the clinicopathologic features and T-cell receptor (TCR) gene rearrangements in Chinese patients with hepatosplenic gammadelta T-cell lymphoma. Findings highlight specific immunophenotypic markers and genetic alterations in this rare lymphoma subtype.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Hepatosplenic gammadelta T-cell lymphoma is a rare and aggressive non-Hodgkin lymphoma.
- Understanding its clinicopathologic and immunophenotypic characteristics is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the clinicopathologic characteristics, immunophenotype, and T-cell receptor (TCR) gene rearrangements.
- To analyze these features in eight Chinese patients with hepatosplenic gammadelta T-cell lymphoma.
Main Methods:
- Review of clinicopathologic data and hematoxylin-eosin-stained slides.
- Immunohistochemical staining for CD3, CD4, CD8, CD20, CD43, CD56, CD79a, UCHL-1, and TCR gammadelta.
- Polymerase chain reaction (PCR) analysis for TCR gamma and delta chain gene rearrangements.
Main Results:
- Splenomegaly and infiltration of lymphoma cells in the spleen and liver sinusoids were observed.
- Immunohistochemistry revealed positivity for CD3, CD43, and CD56 in all cases, with CD8 positivity in four cases and CD4 negativity in all cases.
- Monoclonal rearrangements of TCR gamma and delta genes were detected in a majority of the cases.
Conclusions:
- The clinicopathology of hepatosplenic gammadelta T-cell lymphoma in Chinese patients aligns with previous reports, with notable findings of less massive splenomegaly and frequent CD8 positivity.
- TCR gene rearrangements are common, aiding in the diagnosis of this lymphoma subtype.