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[Devic's optic neuromyelitis and pulmonary tuberculosis].

H El Otmani1, M A Rafai, F Moutaouakil

  • 1Service de Neurologie, CHU Ibn Rochd, Casablanca, Maroc. hichamotmani@caramail.com

Revue Des Maladies Respiratoires
|June 22, 2005
PubMed
Summary
This summary is machine-generated.

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This case report details a rare instance of Devic's syndrome (neuromyelitis optica) in a patient with active pulmonary tuberculosis. The condition, likely an immune response to the infection, resulted in blindness despite treatment.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Devic's syndrome, also known as neuromyelitis optica, is a rare autoimmune disorder targeting the optic nerves and spinal cord.
  • A rare association between Devic's syndrome and active pulmonary tuberculosis has been documented in limited case reports.

Observation:

  • A 40-year-old patient with active pulmonary tuberculosis developed sudden bilateral blindness, followed by paraplegia and sphincter dysfunction.
  • Investigations ruled out direct central nervous system tuberculosis or adverse reactions to anti-tuberculosis medications.

Findings:

  • The patient was diagnosed with Devic's syndrome based on established diagnostic criteria.
  • Treatment with corticosteroids and anti-tuberculosis chemotherapy led to recovery of motor and sphincter function, but vision loss was permanent.

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Implications:

  • This case underscores the rarity of Devic's syndrome co-occurring with pulmonary tuberculosis.
  • The underlying pathophysiology is hypothesized to involve an immune dysfunction triggered by mycobacterial infection, leading to neurological damage.