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Nervous Tissue: Myelin01:25

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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Related Experiment Video

Updated: Jan 19, 2026

Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation
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Eroded myelin figures.

M A Arunagirinathan, C Manohar, Jayesh R Bellare

    Langmuir : the ACS Journal of Surfaces and Colloids
    |June 23, 2005
    PubMed
    Summary

    Unusual myelin figures with rough surfaces, termed eroded myelin, form when Tween85 contacts water. These structures exhibit unique growth and stability, differing from typical smooth myelin forms.

    Area of Science:

    • Colloid and Surface Science
    • Materials Science
    • Biophysics

    Background:

    • Myelin figures, typically smooth rod-like structures formed by surfactants in water, exhibit normal morphology with other surfactants.
    • Contact between Tween85 and water results in the formation of myelin figures with atypical surface characteristics.

    Discussion:

    • Myelin figures formed with Tween85 and water display irregular, rough surfaces with adhered vesicle-like structures, distinct from smooth forms.
    • These 'eroded myelin figures' can coexist with smooth areas on the same structure, with transformation from smooth to eroded being common, but not vice versa.
    • Eroded myelin figures demonstrate unique developmental pathways, with tentacle-like extensions forming new myelin and expelling vesicles.

    Key Insights:

    • Eroded myelin figures are more stable than smooth forms, particularly within a temperature range of 22-42°C.

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  • Above 42°C, only smooth myelin figures are observed, indicating a temperature-dependent morphological transition.
  • The study identifies a novel surfactant-induced morphological transformation in myelin figures with implications for self-assembly and materials science.

    • Outlook:

    • Further investigation into the precise mechanisms driving the transformation and stability of eroded myelin figures.
    • Exploring potential applications of these unique structures in areas like drug delivery or nanotechnology.
    • Comparative studies with other non-ionic surfactants to understand the specificity of Tween85-induced morphology.