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Updated: Aug 17, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[A case of sarcoidosis with diffuse pulmonary arteriovenous malformations]
Hiroomi Kuwahara1, Tadaaki Yamada, Tatsuya Yuba
1Division of Pulmonary Medcine, Kyoto Prefectural University of Medicine.
Abstract:
A 27-year-old woman was admitted because of right dry eye and blurred vision. She was given a diagnosis of uveitis due to sarcoidosis. Chest X-ray film showed bilateral hilar lymphadenopathy and multiple nodules in both lungs. The nodules were considered to be associated with sarcoidosis. However chest CT demonstrated that the nodules were well-defined and connected with two vessels. We diagnosed diffuse pulmonary arteriovenous malformations (AVMs) by 3D-CT. In three of sixteen AVMs, the feeding vessels were more than 3 mm wide in diameter on pulmonary arteriography, and those were embolized by platinum coils. The embolotherapy of diffuse AVMs could not ameliorate the shunt fraction sufficiently, but should reduce the possibility of the catastrophic complication of brain abscess.
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