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Higher brachial-ankle pulse wave velocity is associated with more advanced carotid atherosclerosis in end-stage renal

Masanori Munakata1, Junko Sakuraba, Jun Tayama

  • 1Preventive Medical Center, Tohoku Rosai Hospital, Sendai, Japan. munakata@tohokuh.rofuku.go.jp

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|June 23, 2005
PubMed

Insights

Higher brachial-ankle pulse wave velocity indicates increased arterial stiffness and is a risk factor for carotid atherosclerosis in end-stage renal disease patients. This association is independent of wave reflection effects on central arterial pressure.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Vascular Biology

Background:

  • Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is a significant indicator of cardiovascular risk.
  • End-stage renal disease (ESRD) is associated with accelerated vascular aging and increased arterial stiffness.
  • The relationship between baPWV, carotid atherosclerosis, and left ventricular hypertrophy (LVH) in ESRD patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between higher baPWV and advanced carotid atherosclerosis in ESRD patients.
  • To determine if higher baPWV is linked to left ventricular hypertrophy (LVH) in ESRD.
  • To explore the mediating role of wave reflection on central arterial pressure in these associations.

Main Methods:

  • Sixty-eight ESRD patients underwent measurements of blood pressure, baPWV, and augmentation index (AI).
  • Carotid atherosclerosis was quantified using plaque score and maximum intimal-medial thickness.
  • Left ventricular mass index (LVMI) was assessed via echocardiography.

Main Results:

  • baPWV showed significant correlations with both plaque score (r = 0.420, p < 0.001) and maximum intimal-medial thickness (r = 0.452, p < 0.0005).
  • baPWV was an independent risk factor for carotid plaque score and intimal-medial thickness.
  • baPWV was not correlated with LVMI or AI in ESRD patients.

Conclusions:

  • Elevated baPWV is an independent risk factor for carotid atherosclerosis in ESRD patients.
  • The association between baPWV and carotid atherosclerosis is independent of wave reflection effects.
  • baPWV is not associated with left ventricular structure in this ESRD cohort.

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