Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism

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Published on: February 14, 2018

Ken-Ichi Fujita1, Isao Kubo

  • 1Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720-3112, USA.

Journal of Agricultural and Food Chemistry
|June 23, 2005
PubMed

Insights

Polygodial demonstrates potent fungicidal activity against Zygosaccharomyces bailii by disrupting cell membranes. Its efficacy is significantly boosted when combined with anethole or sorbic acid, enhancing food preservation potential.

Area of Science:

  • Food Microbiology
  • Natural Product Chemistry
  • Mycology

Background:

  • Food spoilage yeasts like Zygosaccharomyces bailii pose significant challenges to food preservation.
  • Natural compounds are increasingly explored for their antimicrobial properties as alternatives to synthetic preservatives.

Purpose of the Study:

  • To evaluate the fungicidal activity of polygodial against Zygosaccharomyces bailii.
  • To investigate the synergistic effects of polygodial in combination with anethole and sorbic acid.

Main Methods:

  • Determination of minimum fungicidal concentration (MFC) for polygodial.
  • Time-kill curve analysis to assess fungicidal kinetics.
  • Evaluation of synergistic fungicidal effects in binary combinations.

Main Results:

  • Polygodial exhibited a minimum fungicidal concentration of 50 microg/mL against Zygosaccharomyces bailii.
  • Polygodial acts by disrupting yeast cell membranes and decreasing plasma membrane fluidity.
  • Combinations with anethole or sorbic acid resulted in significant synergistic fungicidal activity, with enhancements up to 512-fold.

Conclusions:

  • Polygodial is an effective fungicide against Zygosaccharomyces bailii.
  • Synergistic combinations of polygodial with anethole or sorbic acid show promise for enhanced food preservation strategies.

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