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[Antimalarials in systemic diseases]
1Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro, Madrid.
Revista Clinica Espanola
|June 23, 2005
Summary
Antimalarials, used for centuries, treat autoimmune diseases like rheumatoid arthritis and lupus. These drugs offer benefits for skin and joint issues, with careful consideration for pregnant women due to potential retinal side effects.
Area of Science:
- Pharmacology
- Rheumatology
- Immunology
Context:
- Antimalarials have a long history of use, with chloroquine and hydroxychloroquine being widely prescribed.
- Their mechanisms of action in autoimmune conditions are not fully understood.
- These drugs are frequently employed in managing autoimmune diseases such as rheumatoid arthritis and lupus erythematosus.
Purpose:
- To review the use of antimalarials in autoimmune diseases.
- To discuss their efficacy, adverse effects (particularly retinal), and appropriate dosing.
- To provide guidance on their use in pregnant women.
Summary:
- Antimalarials demonstrate efficacy in treating cutaneous and articular manifestations of autoimmune diseases.
- Benefits extend to improving blood glucose, lipid profiles, and platelet aggregation.
- The favorable effectiveness-toxicity ratio supports their consideration in managing autoimmune conditions.
Impact:
- Provides a comprehensive overview of antimalarial therapy in autoimmune disorders.
- Highlights key considerations for clinical practice, including dosing and adverse event monitoring.
- Offers insights into the management of autoimmune diseases, especially in specific populations like pregnant women.