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Updated: Aug 10, 2026
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Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
Cross talk of signaling and apoptotic cascades in the CNS: target for virus modulation
1Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. laurelia@umaryland.edu
Frontiers in Bioscience : a Journal and Virtual Library
|June 23, 2005
Abstract:
Signaling cascades that regulate proliferation, differentiation and apoptosis determine cell life and death decisions. All are targets of virus modulation. These cascades are briefly described in this review, underscoring cross talk and the integration of distinct signals that contribute to central nervous system (CNS) disease.
Insights
Viruses can manipulate cell signaling pathways controlling proliferation, differentiation, and apoptosis. This review highlights how these pathways
Area of Science:
- Cellular biology
- Neuroscience
- Virology
Background:
- Cellular signaling cascades govern critical life and death decisions, including proliferation, differentiation, and apoptosis.
- These fundamental biological processes are frequently hijacked by viruses for their own replication and propagation.
Purpose of the Study:
- To review the key signaling cascades involved in cell life and death decisions.
- To emphasize the role of viral modulation of these pathways.
- To explore the integration of distinct signals and cross-talk in the context of central nervous system (CNS) disease.
Main Methods:
- Literature review of signaling pathways.
- Analysis of viral interference mechanisms.
- Integration of findings related to CNS pathology.
Main Results:
- Detailed description of signaling cascades regulating cell proliferation, differentiation, and apoptosis.
- Evidence of viral targeting and modulation of these pathways.
- Identification of cross-talk and signal integration as crucial factors in CNS disease pathogenesis.
Conclusions:
- Viral modulation of cellular signaling is a significant factor in disease development.
- Understanding signal integration and cross-talk is essential for deciphering the mechanisms of CNS diseases caused by viruses.
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