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Related Experiment Videos

Is schizophrenia associated with narcolepsy?

Mark Walterfang1, Edward Upjohn, Dennis Velakoulis

  • 1Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia. mark.walterfang@mh.org.au

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology
|June 23, 2005
PubMed
Summary
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Schizophrenia-like psychosis in narcolepsy is rarely a distinct condition. It is typically medication-related or coincidental, with limited evidence for shared neurobiology between these disorders.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Sleep Medicine

Background:

  • A potential link between schizophrenia and narcolepsy has been suggested.
  • Schizophrenia-like psychosis has been observed in narcolepsy patients and with narcolepsy treatments.

Observation:

  • This study investigated two patients with schizophrenia-like psychosis and narcolepsy.
  • A literature review explored potential shared neurobiology between narcolepsy and schizophrenia.

Findings:

  • Examination of symptoms, human leukocyte antigen (HLA) associations, rapid eye movement (REM) sleep architecture, D2-dopamine receptor changes, and hypocretinergic function revealed minimal common pathology.
  • Limited evidence supports a distinct psychosis originating from narcolepsy.

Implications:

Related Experiment Videos

  • Schizophrenia-like psychosis in narcolepsy is likely due to medication side effects or chance.
  • Further research may clarify the infrequent co-occurrence of these conditions.