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Updated: Aug 17, 2026

Cross-Modal Multivariate Pattern Analysis
Published on: November 9, 2011
Audiovisual peduncular hallucinations: a release of cross-modal integration sites?
Kirsten I Taylor1, Peter Brugger, Urs Schwarz
1Department of Neurology, University Hospital Zürich, Zürich, Switzerland.
Abstract:
We report the case of a patient with multiple sclerosis with congruent visual and auditory hallucinations of deceased familiar persons that lasted continuously for several days. Magnetic resonance imaging revealed an isolated, predominantly left-sided lesion in the periaqueductal segment of the mesencephalon. We propose that these hallucinations represent a bimodal variant of classic peduncular hallucinations, brought about by a deregulation of modulatory superior collicular activity and a release of cross-modal integrative functions of the superior temporal sulcus.
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