Related Experiment Video
Updated: Aug 1, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
Published on: May 9, 2017
AID to overcome the limitations of genomic information
Tasuku Honjo1, Hitoshi Nagaoka, Reiko Shinkura
1Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida Sakyo-Ku, Kyoto 606-8501 Japan. honjo@mfour.med.kyoto-u.ac.jp <honjo@mfour.med.kyoto-u.ac.jp>
Abstract:
The limitations of genomic information forced our ancestors to adopt a strategy for introducing somatic DNA alterations with the risk of genome instability. Although activation-induced deaminase (AID) is involved in DNA cleavage in somatic hypermutation and class-switch recombination, its mechanism of action has been debated extensively, with the two main hypotheses being distinguished by the chief target of AID: RNA or DNA. The principle distinction between the two hypotheses is the requirement for translation of edited mRNA or uracil removal from DNA for DNA cleavage. Although a series of experiments has provided support for the 'RNA-editing' hypothesis and requires reevaluation of the 'DNA-deamination' hypothesis, definitive proof is yet to come.
More Related Videos
Related Concept Videos
Genomics
Evolutionary Relationships through Genome Comparisons
Genome Annotation and Assembly
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets
Modern Molecular Taxonomy

