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An integrated disposable dye clad leaky waveguide sensor for micro-TAS applications.

Mohammed Zourob1, Stephan Mohr, Peter R Fielden

  • 1School of Chemical Engineering and Analytical Science, The University of Manchester, P. O. Box 88, Sackville Street, Manchester, M60 1QD, UK. m.zourob@manchester.ac.uk

Lab on a Chip
|June 23, 2005
PubMed
Summary

A novel disposable dye clad leaky waveguide (DCLW) device offers sensitive refractive index and fluorescence detection for micro total analysis systems (mu-TAS). This integrated waveguide chip enables cost-effective, high-performance sensing applications.

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Area of Science:

  • Optoelectronics
  • Analytical Chemistry
  • Materials Science

Background:

  • Micro total analysis systems (mu-TAS) require integrated, sensitive detection methods.
  • Existing waveguide technologies face challenges in cost-effective fabrication and sensitivity.

Purpose of the Study:

  • To develop and validate an integrated, disposable dye clad leaky waveguide (DCLW) device.
  • To enable sensitive refractive index and fluorescence detection within mu-TAS.

Main Methods:

  • Fabrication of DCLW chips using spin-coating of dye and silica sol-gel layers on a polymer substrate.
  • Integration of injection-molded grating couplers for optical coupling.
  • Testing for refractive index changes in glycerol solutions and fluorescence detection of fluorescein.

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Main Results:

  • Demonstrated successful fabrication of disposable DCLW chips at room temperature.
  • Achieved sensitive detection of refractive index variations.
  • Detected fluorescein concentrations as low as 10(-12) M using the grating coupler.

Conclusions:

  • The DCLW device is a simple, inexpensive, and robust platform for mu-TAS.
  • The integrated design enhances light-sample interaction for improved sensitivity.
  • This technology holds promise for advanced microfluidic sensing applications.