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Androstane and withanolides from Physalis cinerascens
Emma Maldonado1, Vita E Alvarado, Fernando R Torres
1Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México. emmamaldonado@correo.unam.mx
Planta Medica
|June 23, 2005
Summary
Researchers isolated novel withanolides, cinerolide and 24,25-dihydrowithanolide S, and a new androstane, cinedione, from Physalis cinerascens. Their structures were elucidated using spectroscopic methods and X-ray diffraction.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Physalis cinerascens is a plant species known for its potential medicinal properties.
- Withanolides are a class of sterically hindered, naturally occurring withanolide triterpenoids with a wide range of biological activities.
Purpose of the Study:
- To isolate and characterize chemical constituents from Physalis cinerascens.
- To identify novel compounds with potential therapeutic applications.
Main Methods:
- Extraction of plant material (leaves, flowers, and stems) using ethyl acetate.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (NMR, MS).
- Confirmation of structure for cinerolide via X-ray diffraction analysis.
Main Results:
- Isolation of two new withanolides: cinerolide and 24,25-dihydrowithanolide S.
- Isolation of a new androstane: cinedione.
- Isolation of four known withanolides: visconolide, physalactone, withanolide S, and 4beta-hydroxywithanolide E.
- Complete structural determination of all isolated compounds.
Conclusions:
- Physalis cinerascens is a rich source of diverse withanolides and androstanes.
- The discovery of new compounds like cinerolide and cinedione expands the known chemical diversity of this plant genus.
- Further investigation into the biological activities of these isolated compounds is warranted.