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Updated: Aug 11, 2026
23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Speaking the same language: treatment outcome definitions for multidrug-resistant tuberculosis
K F Laserson1, L E Thorpe, V Leimane
1Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. kel4@cdc.gov
Summary
Standardized definitions for multidrug-resistant tuberculosis (MDR-TB) patient registration and treatment outcomes were developed. These definitions will help assess and compare MDR-TB program performance globally.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Global Health
Background:
- An estimated 273,000 new multidrug-resistant tuberculosis (MDR-TB) cases occurred globally in 2000.
- The DOTS-Plus strategy aims to manage MDR-TB but lacks standardized definitions for patient registration and treatment outcomes.
Purpose of the Study:
- To propose standardized case registration groups and treatment outcome definitions for MDR-TB.
- To establish procedures for cohort analyses under the DOTS-Plus strategy.
Main Methods:
- A two-year process involving meetings, conferences, and correspondence was conducted.
- Published definitions for drug-susceptible TB and international program experience were reviewed to reach agreement.
Main Results:
- Definitions were created for MDR-TB patient categorization, smear and culture conversion, and treatment outcomes (cure, completion, death, default, failure, transfer out).
- Standards for conducting outcome analyses were developed to ensure program comparability.
Conclusions:
- Standardized definitions and cohort analyses are crucial for assessing and comparing MDR-TB program performance.
- This will contribute evidence to inform decision-making for MDR-TB control strategies.
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